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672315 Ursolic Acid - CAS 77-52-1 - Calbiochem

A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.

Ursolic Acid - CAS 77-52-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII

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672315
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Tableau de caractéristiques principal

CAS #Empirical Formula
77-52-1C₃₀H₄₈O₃

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672315-50MG
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      Description
      OverviewA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
      Catalogue Number672315
      Brand Family Calbiochem®
      Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
      References
      ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
      Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
      Jung, S.H., et al. 2007. Biochem. J. 403, 243.
      Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
      Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
      Product Information
      CAS number77-52-1
      FormWhite powder
      Hill FormulaC₃₀H₄₈O₃
      Chemical formulaC₃₀H₄₈O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by GC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      672315-50MG 04055977184136

      Documentation

      Ursolic Acid - CAS 77-52-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ursolic Acid - CAS 77-52-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      672315

      Références bibliographiques

      Aperçu de la référence bibliographique
      Li, Y., et al. 2010. Int. J. Cancer 127, 462.
      Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
      Jung, S.H., et al. 2007. Biochem. J. 403, 243.
      Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
      Shishodia, S., et al. 2003. Cancer Res. 63, 4375.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-December-2023 JSW
      Synonyms3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
      DescriptionA cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number77-52-1
      Chemical formulaC₃₀H₄₈O₃
      Structure formulaStructure formula
      Purity≥90% by GC
      SolubilityDimethylformamide or DMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLi, Y., et al. 2010. Int. J. Cancer 127, 462.
      Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943.
      Jung, S.H., et al. 2007. Biochem. J. 403, 243.
      Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505.
      Shishodia, S., et al. 2003. Cancer Res. 63, 4375.