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654380 Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

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654380
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
11089-65-9C₃₉H₆₄N₄O₁₆

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654380-50MG
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      Description
      OverviewA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
      Catalogue Number654380
      Brand Family Calbiochem®
      References
      ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
      Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
      Product Information
      CAS number11089-65-9
      FormWhite to off-white solid
      Hill FormulaC₃₉H₆₄N₄O₁₆
      Chemical formulaC₃₉H₆₄N₄O₁₆
      ReconstitutionAqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetN-linked glycosylation
      Secondary targetthrombin-induced Ca2+ mobilization in cells
      Purity≥98% by HPLC (A+B+C+D)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYO7980200
      Safety Information
      R PhraseR: 26/27/28-60-61

      Very toxic by inhalation, in contact with skin and if swallowed.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      654380-50MG 04055977184693

      Documentation

      Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      654380

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
      Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

      Citations

      Titre
    • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
    • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-September-2007 RFH
      DescriptionA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.
      FormWhite to off-white solid
      CAS number11089-65-9
      RTECSYO7980200
      Chemical formulaC₃₉H₆₄N₄O₁₆
      Structure formulaStructure formula
      Purity≥98% by HPLC (A+B+C+D)
      SolubilityDMSO (10 mg/ml), DMF, or Pyridine. Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 9819
      ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
      Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
      Citation
    • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
    • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•