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613551 TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem

TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).

TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01

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613551
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Tableau de caractéristiques principal

CAS #Empirical Formula
552309-42-9C₁₉H₂₀N₄O₃S₂

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613551-5MG
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      Description
      OverviewAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
      Catalogue Number613551
      Brand Family Calbiochem®
      SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
      References
      ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
      Namkung, W., et al. 2011., J Biol Chem. in press.
      Namkung, W., et al. 2011., FASEB J. in press.
      Product Information
      CAS number552309-42-9
      FormOff-white powder
      Hill FormulaC₁₉H₂₀N₄O₃S₂
      Chemical formulaC₁₉H₂₀N₄O₃S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationTMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      613551-5MG 04055977263824