613551 Sigma-AldrichTMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
More>> TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Less<<Synonymes: ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
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Aperçu
Tableau de caractéristiques principal
CAS # | Empirical Formula |
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552309-42-9 | C₁₉H₂₀N₄O₃S₂ |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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613551-5MG |
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Flacon en verre | 5 mg |
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Description | |
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Overview | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. |
Catalogue Number | 613551 |
Brand Family | Calbiochem® |
Synonyms | ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01 |
References | |
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References | Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press Namkung, W., et al. 2011., J Biol Chem. in press. Namkung, W., et al. 2011., FASEB J. in press. |
Product Information | |
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CAS number | 552309-42-9 |
Form | Off-white powder |
Hill Formula | C₁₉H₂₀N₄O₃S₂ |
Chemical formula | C₁₉H₂₀N₄O₃S₂ |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). |
Biological Information | |
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Purity | ≥97% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Référence | GTIN |
613551-5MG | 04055977263824 |