613551 Sigma-AldrichTMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
More>> TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Less<<TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 552309-42-9 | C₁₉H₂₀N₄O₃S₂ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 613551-5MG |
|
Flacon en verre | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. |
| Catalogue Number | 613551 |
| Brand Family | Calbiochem® |
| Synonyms | ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01 |
| References | |
|---|---|
| References | Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press Namkung, W., et al. 2011., J Biol Chem. in press. Namkung, W., et al. 2011., FASEB J. in press. |
| Product Information | |
|---|---|
| CAS number | 552309-42-9 |
| Form | Off-white powder |
| Hill Formula | C₁₉H₂₀N₄O₃S₂ |
| Chemical formula | C₁₉H₂₀N₄O₃S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 613551-5MG | 04055977263824 |
Documentation
TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem FDS
| Titre |
|---|
TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 613551 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press Namkung, W., et al. 2011., J Biol Chem. in press. Namkung, W., et al. 2011., FASEB J. in press. |
| Fiche technique | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|