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613570 TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem

The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ant-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)

Primary Target: LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
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613570
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₆₃H₂₆₈N₅₂O₃₈S

Prix & Disponibilité

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613570-1MG
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      Description
      OverviewA cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
      Catalogue Number613570
      Brand Family Calbiochem®
      SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
      References
      ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      613570-1MG 04055977263558

      Documentation

      TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      613570

      Références bibliographiques

      Aperçu de la référence bibliographique
      Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.

      Brochure

      Titre
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
      DescriptionA synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.