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580563 TCPOBOP - CAS 76150-91-9 - Calbiochem

The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.

TCPOBOP - CAS 76150-91-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene

Primary Target: Cytochrome P450 (CYP)-inducing agents
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580563
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Tableau de caractéristiques principal

CAS #Empirical Formula
76150-91-9C₁₆H₈Cl₄N₂O₂

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580563-25MG
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      		 Ampoule plast. 25 mg
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      Description
      OverviewThe most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.
      Catalogue Number580563
      Brand Family Calbiochem®
      Synonyms1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
      References
      ReferencesLedda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
      Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
      Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
      Forman, B.M., et al. 1998. Nature 395, 612.
      Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
      Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
      Smith, G., et al. 1993. Biochem. J. 289, 807.
      Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
      Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.
      Product Information
      CAS number76150-91-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₈Cl₄N₂O₂
      Chemical formulaC₁₆H₈Cl₄N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCytochrome P450 (CYP)-inducing agents
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUT7145000
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      580563-25MG 04055977265576

      Documentation

      TCPOBOP - CAS 76150-91-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      TCPOBOP - CAS 76150-91-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      580563

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
      Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
      Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
      Forman, B.M., et al. 1998. Nature 395, 612.
      Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
      Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
      Smith, G., et al. 1993. Biochem. J. 289, 807.
      Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
      Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      Synonyms1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
      DescriptionA highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number76150-91-9
      RTECSUT7145000
      Chemical formulaC₁₆H₈Cl₄N₂O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesLedda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
      Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
      Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
      Forman, B.M., et al. 1998. Nature 395, 612.
      Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
      Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
      Smith, G., et al. 1993. Biochem. J. 289, 807.
      Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
      Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.