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567750 Splitomicin - CAS 5690-03-9 - Calbiochem

A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM).

Splitomicin - CAS 5690-03-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Primary Target: NAD+-dependent histone deacetylase activity of Sir2 protein
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567750
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Tableau de caractéristiques principal

CAS #Empirical Formula
5690-03-9C₁₃H₁₀O₂

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567750-5MG
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      Description
      OverviewA cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
      Catalogue Number567750
      Brand Family Calbiochem®
      Synonyms1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
      References
      ReferencesBedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.
      Product Information
      CAS number5690-03-9
      ATP CompetitiveN
      FormOff-white powder
      Hill FormulaC₁₃H₁₀O₂
      Chemical formulaC₁₃H₁₀O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNAD+-dependent histone deacetylase activity of Sir2 protein
      Primary Target IC<sub>50</sub>60 µM against NAD+-dependent histone deacetylase activity of Sir2 protein
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      567750-5MG 04055977190946

      Documentation

      Splitomicin - CAS 5690-03-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Splitomicin - CAS 5690-03-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      567750

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.

      Brochure

      Titre
      Overnight Express Autoinduction Systems

      Informations techniques

      Titre
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      Synonyms1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
      DescriptionA cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 µM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5690-03-9
      Chemical formulaC₁₃H₁₀O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.