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573103 STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem

The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ethyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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573103
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1041438-68-9C₁₉H₇F₇N₂O₃

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573103-5MG
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      Description
      OverviewA cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC50 against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.
      Catalogue Number573103
      Brand Family Calbiochem®
      SynonymsEthyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
      References
      ReferencesXu, J., et al. 2008. J. Med. Chem. 51, 4115.
      Product Information
      CAS number1041438-68-9
      FormWhite to light orange solid
      Hill FormulaC₁₉H₇F₇N₂O₃
      Chemical formulaC₁₉H₇F₇N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      573103-5MG 04055977266443

      Documentation

      STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      573103

      Références bibliographiques

      Aperçu de la référence bibliographique
      Xu, J., et al. 2008. J. Med. Chem. 51, 4115.

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-December-2023 JSW
      SynonymsEthyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
      DescriptionA cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC50 against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.
      FormWhite to light orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1041438-68-9
      Chemical formulaC₁₉H₇F₇N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesXu, J., et al. 2008. J. Med. Chem. 51, 4115.