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566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem

SIRT1 Inhibitor IV, (S)-35, CAS 848193-72-6, is a cell-permeable, entiomerically pure compound that displays similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide

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566325
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Tableau de caractéristiques principal

CAS #Empirical Formula
848193-72-6C₁₄H₁₅ClN₂O

Prix & Disponibilité

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566325-500UG
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      Description
      OverviewA cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 min in mice in vivo.
      Catalogue Number566325
      Brand Family Calbiochem®
      Synonyms(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
      Application Data
      References
      ReferencesNapper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
      Product Information
      CAS number848193-72-6
      FormOff-white solid
      Hill FormulaC₁₄H₁₅ClN₂O
      Chemical formulaC₁₄H₁₅ClN₂O
      Quality LevelMQ100
      Applications
      ApplicationSIRT1 Inhibitor IV, (S)-35, CAS 848193-72-6, is a cell-permeable, entiomerically pure compound that displays similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322).
      Biological Information
      Purity≥96% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      566325-500UG 04055977191424

      Documentation

      SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      566325

      Références bibliographiques

      Aperçu de la référence bibliographique
      Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.

      Fiche technique

      Titre
      SIRTainty™ Class III HDAC Assay
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2009 RFH
      Synonyms(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
      Application Data
      DescriptionA cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number848193-72-6
      Chemical formulaC₁₄H₁₅ClN₂O
      Purity≥96% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesNapper, A.D., et al. 2005. J. Med. Chem. 48, 8045.