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506417 SB 242084 Hydrochloride - CAS 1260505-34-7 - Calbiochem

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Synonymes: 5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride

Primary Target: 5-HT2C
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506417
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Tableau de caractéristiques principal

CAS #Empirical Formula
1260505-34-7C₂₁H₁₉ClN₄O₂·HCl

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      		 Flacon en verre 10 mg
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      Description
      OverviewA selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
      Catalogue Number506417
      Brand Family Calbiochem®
      Synonyms5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
      References
      ReferencesManvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
      Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
      Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
      Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
      Product Information
      CAS number1260505-34-7
      FormOff-white to pale yellow solid
      Hill FormulaC₂₁H₁₉ClN₄O₂·HCl
      Chemical formulaC₂₁H₁₉ClN₄O₂·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT2C
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5064170001 04055977243338

      Documentation

      SB 242084 Hydrochloride - CAS 1260505-34-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
      Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
      Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
      Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-June-2023 JSW
      Synonyms5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
      DescriptionA selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
      FormOff-white to pale yellow solid
      CAS number1260505-34-7
      Chemical formulaC₂₁H₁₉ClN₄O₂·HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mM) or H₂O (50 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesManvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
      Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
      Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
      Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.