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559396 SB 220025

A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).

SB 220025 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

Primary Target: P38MAPK
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559396
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
165806-53-1C₁₈H₁₉FN₆

Prix & Disponibilité

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559396-500UG
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      		 Ampoule plast. 500 μg
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      Description
      OverviewA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number559396
      Brand Family Calbiochem®
      Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
      References
      ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.
      Product Information
      CAS number165806-53-1
      FormWhite to pale yellow solid
      Hill FormulaC₁₈H₁₉FN₆
      Chemical formulaC₁₈H₁₉FN₆
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP38MAPK
      Primary Target IC<sub>50</sub>60 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      559396-500UG 07790788051549

      Documentation

      SB 220025 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SB 220025 Certificats d'analyse

      TitreNuméro de lot
      559396

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2014 JSW
      Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
      DescriptionA potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
      FormWhite to pale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number165806-53-1
      Chemical formulaC₁₈H₁₉FN₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (22 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
      Wang, Z., et al. 1998. Structure 6, 1117.

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors