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559388 SB 202190 - CAS 152121-30-7 - Calbiochem

SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC₅₀ = 350 nM).

SB 202190 - CAS 152121-30-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II

Primary Target: p38β
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559388
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Tableau de caractéristiques principal

CAS #Empirical Formula
152121-30-7C₂₀H₁₄FN₃O

Prix & Disponibilité

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559388-1MG
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      Description
      OverviewA potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
      Catalogue Number559388
      Brand Family Calbiochem®
      Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
      References
      ReferencesDavies, S.P., et al. 2000. Biochem. J. 351, 95.
      Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, J.C., et al. 1994. Nature 372, 739.
      Product Information
      CAS number152121-30-7
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₂₀H₁₄FN₃O
      Chemical formulaC₂₀H₁₄FN₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp38β
      Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
      Primary Target K<sub>i</sub>16 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      559388-1MG 04055977192476

      Documentation

      SB 202190 - CAS 152121-30-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SB 202190 - CAS 152121-30-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      559388

      Références bibliographiques

      Aperçu de la référence bibliographique
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, J.C., et al. 1994. Nature 372, 739.

      Citations

      Titre
    • Annika Grabbe and Jurgen Wienands. (2006) Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood 108, 3761-3768.
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
      DescriptionA potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells.
      FormPale yellow solid
      CAS number152121-30-7
      Chemical formulaC₂₀H₁₄FN₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDavies, S.P., et al. 2000. Biochem. J. 351, 95.
      Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, J.C., et al. 1994. Nature 372, 739.
      Citation
    • Annika Grabbe and Jurgen Wienands. (2006) Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. Blood 108, 3761-3768.
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
      		•

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors