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524403 Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Primary Target: AMG-CoA reductase
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524403
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Tableau de caractéristiques principal

CAS #Empirical Formula
81131-70-6C₂₃H₃₅O₇.Na

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524403-25MG
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      Description
      OverviewA water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
      Catalogue Number524403
      Brand Family Calbiochem®
      Synonyms(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
      References
      ReferencesKwak, B., et al. 2000. Natl. Med. 6, 1399.
      Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
      Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
      Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
      Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
      Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
      Product Information
      CAS number81131-70-6
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₂₃H₃₅O₇.Na
      Chemical formulaC₂₃H₃₅O₇.Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAMG-CoA reductase
      Primary Target K<sub>i</sub>~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQJ7185000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Environmental Hazard
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      524403-25MG 04055977270983

      Documentation

      Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      524403

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kwak, B., et al. 2000. Natl. Med. 6, 1399.
      Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
      Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
      Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
      Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
      Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      Synonyms(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
      DescriptionA water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (Ki ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number81131-70-6
      RTECSQJ7185000
      Chemical formulaC₂₃H₃₅O₇.Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Environmental Hazard
      Merck USA index14, 7714
      ReferencesKwak, B., et al. 2000. Natl. Med. 6, 1399.
      Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
      Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
      Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
      Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
      Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179