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23-046M Parkin (c-Myc tagged) Protein, active, 250 µg

Active, full length, recombinant human Parkin. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

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Key Applications: Enzyme Assays
23-046M
250 µg  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman E3
      Description
      Catalogue Number23-046M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionParkin (c-Myc tagged) Protein, active, 250 µg
      Alternate Names
      • Parkinson juvenile disease protein 2
      • PARK2
      • PRKN
      Background InformationParkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the α-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, full length, recombinant human Parkin. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      23-046M 04053252596834

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      23-046 Parkin (c-Myc tagged) Protein, active, 10 µg Prix & Disponibilité

      Familles de produits

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
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      Catégories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases