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370655 PKG Iα Inhibitor, Cell-Permeable - Calbiochem

The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG Iα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: DT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII

Primary Target: PKG1α
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370655
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₅₂H₂₅₈N₅₂O₂₈S

Prix & Disponibilité

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370655-1MG
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      Description
      OverviewA highly potent, reversible, and substrate competitive membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Iα (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µM). Inhibits protein kinase A at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
      Catalogue Number370655
      Brand Family Calbiochem®
      SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
      References
      ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Product Information
      ATP CompetitiveY
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG1α
      Primary Target K<sub>i</sub>25 nM against protein kinase G Iα
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      370655-1MG 04055977191653

      Documentation

      PKG Iα Inhibitor, Cell-Permeable - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PKG Iα Inhibitor, Cell-Permeable - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      370655

      Références bibliographiques

      Aperçu de la référence bibliographique
      Dostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
      DescriptionA highly potent, reversible, and substrate competitive membrane-permeable peptide that selectively inhibits protein kinase G Iα (PKG Iα) (Ki = 25 nM). Inhibitor peptide is fused to the Drosophila Antennapedia homeo domain peptide to allow membrane permeability. Shown to efficiently cross the membrane of arterial smooth muscle cells and inhibit nitric oxide-induced (NO-induced) vasodilation (EC50 = 47 µM). Inhibits protein kinase A (PKA) activity only at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.