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14-506 PKD2 Recombinant Human Protein, Active, 10 µg

Active, N-terminal His6 tagged, recombinant, full length, human PKD2, for use in Kinase Assays.

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14-506
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-506M when ordering the 250 µg size.
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      Replacement Information
      Description
      Catalogue Number14-506
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKD2 Recombinant Human Protein, Active, 10 µg
      OverviewN-terminal His6 tagged, recombinant, full length, human PKD2
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal His6 tagged, recombinant, full length, human PKD2, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
      Gene Symbol
      • PRKD2
      • DKFZP586E0820
      • PKD2
      • nPKC-D2
      • HSPC187
      Protein TargetPKD2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9BZL6 # Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase.
      SIZE: 878 amino acids; 96722 Da
      TISSUE SPECIFICITY: Widely expressed.
      PTM: Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase.
      SIMILARITY: SwissProt: Q9BZL6 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 PH domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Molecular Weight100kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-506M when ordering the 250 µg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-506 04053252627767

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-506M PKD2 Recombinant Human Protein, Active, 250 µg Prix & Disponibilité

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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases