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508957 PDE5 Inhibitor, Cpd7a - CAS 1233518-60-9 - Calbiochem

A cell-permeable, highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC₅₀ = 270 pM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: PDE5
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508957
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Tableau de caractéristiques principal

CAS #Empirical Formula
1233518-60-9C₂₂H₂₀ClN₃O₂

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      Description
      OverviewA cell-permeable, brain permeant, quinoline-based compound that acts as a highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC50 = 270 pM). Exhibits over 10,000 fold greater selectivity over various other phosphodiestrases and trivial activity against PDE VI (IC50 = 339 nM). Shown to increase cGMP levels in mouse hippocampus and attenuates long term potentiation and memory defects in mice with elevated levels of oligomeric Aβ42. It is rapidly absorbed with peak plasma concentration observed at 30 min. Displays desirable pharmacokinetic properties with plasma t1/2 = 1.33 h and brain t1/2 = 1.04 h.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508957
      Brand Family Calbiochem®
      References
      ReferencesFiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.
      Product Information
      CAS number1233518-60-9
      FormCream solid
      Hill FormulaC₂₂H₂₀ClN₃O₂
      Chemical formulaC₂₂H₂₀ClN₃O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE5
      Primary Target IC<sub>50</sub>270 pM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5089570001 04055977261462

      Documentation

      PDE5 Inhibitor, Cpd7a - CAS 1233518-60-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2014 JSW
      DescriptionA cell-permeable, brain permeant, quinoline-based compound that acts as a highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC50 = 270 pM). Exhibits over 10,000 fold greater selectivity over various other phosphodiestrases and trivial activity against PDE VI (IC50 = 339 nM). Shown to increase cGMP levels in mouse hippocampus and attenuates long term potentiation and memory defects in mice with elevated levels of oligomeric Aβ42. It is rapidly absorbed with peak plasma concentration observed at 30 min. Displays desirable pharmacokinetic properties with plasma t1/2 = 1.33 h and brain t1/2 = 1.04 h.
      FormCream solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1233518-60-9
      Chemical formulaC₂₂H₂₀ClN₃O₂
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.