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505758 Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem

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Synonymes: Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP

Primary Target: P2X₇
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505758
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
71997-40-5C₁₀H₁₄N₅O₁₃P₃

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      Description
      OverviewA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
      Catalogue Number505758
      Brand Family Calbiochem®
      SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
      References
      ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
      DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
      Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
      Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
      Product Information
      CAS number71997-40-5
      FormWhite powder
      Hill FormulaC₁₀H₁₄N₅O₁₃P₃
      Chemical formulaC₁₀H₁₄N₅O₁₃P₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP2X₇
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5057580001 04055977243482

      Documentation

      Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Vergani, A., et al. 2013. Diabetes 62, 1665.
      DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
      Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
      Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
      DescriptionA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
      FormWhite powder
      CAS number71997-40-5
      Chemical formulaC₁₀H₁₄N₅O₁₃P₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
      DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
      Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
      Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.