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4995 Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem

Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Strophanthin G

Primary Target: Na+,K+-ATPase
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4995
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Tableau de caractéristiques principal

CAS #Empirical Formula
11018-89-6C₂₉H₄₄O₁₂ · 8H₂O

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      Description
      OverviewInhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
      Catalogue Number4995
      Brand Family Calbiochem®
      SynonymsStrophanthin G
      References
      ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
      Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
      Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
      Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
      Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
      Product Information
      CAS number11018-89-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₉H₄₄O₁₂ · 8H₂O
      Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationOuabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
      Biological Information
      Primary TargetNa+,K+-ATPase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRN3850000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      4995-1GM 04055977199253

      Documentation

      Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      4995

      Références bibliographiques

      Aperçu de la référence bibliographique
      Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
      Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
      Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
      Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
      Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-January-2014 JSW
      SynonymsStrophanthin G
      DescriptionInhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
      FormWhite to off-white solid
      CAS number11018-89-6
      RTECSRN3850000
      Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityHot H₂O (10 mg/ml). Not soluble in room temperature water.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
      Toxicity Toxic
      Merck USA index14 6901
      ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
      Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
      Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
      Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
      Xu, Z.J., et al. 1992. J. Physiol. 456, 405.