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482200 Nimodipine - CAS 66085-59-4 - Calbiochem

An L-type Ca2+ channel blocker.

Nimodipine - CAS 66085-59-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester

Primary Target: L-type Ca2+ channel blocker
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482200
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
66085-59-4C₂₁H₂₆N₂O₇

Prix & Disponibilité

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482200-25MG
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      		 Ampoule plast. 25 mg
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      Description
      OverviewAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells.
      Catalogue Number482200
      Brand Family Calbiochem®
      Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
      References
      ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
      Product Information
      CAS number66085-59-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₁H₂₆N₂O₇
      Chemical formulaC₂₁H₂₆N₂O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetL-type Ca2+ channel blocker
      Primary Target IC<sub>50</sub>36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells
      Purity>98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUS7975500
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      482200-25MG 04055977183498

      Documentation

      Nimodipine - CAS 66085-59-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Nimodipine - CAS 66085-59-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      482200

      Références bibliographiques

      Aperçu de la référence bibliographique
      Zhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-July-2023 JSW
      Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
      DescriptionAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
      FormYellow solid
      CAS number66085-59-4
      RTECSUS7975500
      Chemical formulaC₂₁H₂₆N₂O₇
      Structure formulaStructure formula
      Purity>98% by HPLC
      SolubilityDMSO (25 mg/ml) or methanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 6551
      ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.