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530838 NMD Inhibitor - CAS 307519-88-6 - Calbiochem

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CAS #Empirical Formula
307519-88-6C₂₁H₂₅N₃O₄S

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5308380001
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      Description
      OverviewA cell-permeable tetrahydroquinoxalinyl-thiophenecarboxylate compound that inhibits nonsense-mediated mRNA decay (NMD) in a dose-dependent manner and enhances the stability of premature termination codon (PTC) mutated p53 mRNA in N417 and HDQP-1 cells. However, it does not affect the stability of wild-type p53 in U2OS cells. Shown to dock reversibly within a SMG7 pocket and disrupt SMG7-UPF1 interaction and prevent their complex formation. Acts synergistically with G418 (Cat. No. 345810; 200 µg/ml) to increase p53 expression in p53 PTC mutant cells leading to increase mRNA levels of p21, Bax, and PUMA. Does not display any toxicity (> 50 µM) in multiple cell lines and has no effect on proliferation and protein synthesis in transformed and non-transformed cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530838
      Brand Family Calbiochem®
      SynonymsEthyl 2-(((6,7-dimethyl-3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl)amino)-4,5-dimethyl-3-thiophenecarboxylate, Nonsense-Mediated mRNA Decay Inhibitor 14, NMDI-14
      References
      ReferencesMartin, L., et al. 2014. Cancer Res. 74, 3104.
      Product Information
      CAS number307519-88-6
      FormYellow powder
      Hill FormulaC₂₁H₂₅N₃O₄S
      Chemical formulaC₂₁H₂₅N₃O₄S
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetSMG7
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      5308380001 04055977243000