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399250 NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NOHA, AcOH

Primary Target: liver and macrophage arginase
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399250
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
53598-01-9C₆H₁₄N₄O₃ · CH₃CO₂H

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      Description
      OverviewCell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
      Catalogue Number399250
      Brand Family Calbiochem®
      SynonymsNOHA, AcOH
      References
      ReferencesBoucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
      Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
      Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
      Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
      Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
      Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.
      Product Information
      CAS number53598-01-9
      FormWhite solid
      Hill FormulaC₆H₁₄N₄O₃ · CH₃CO₂H
      Chemical formulaC₆H₁₄N₄O₃ · CH₃CO₂H
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetliver and macrophage arginase
      Primary Target K<sub>i</sub>150 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      399250-5MG 04055977212556

      Documentation

      NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      399250

      Références bibliographiques

      Aperçu de la référence bibliographique
      Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
      Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
      Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
      Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
      Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
      Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

      Brochure

      Titre
      Pathways and Biomarkers of Oxidative Stress
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2023 JSW
      SynonymsNOHA, AcOH
      DescriptionCell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number53598-01-9
      Chemical formulaC₆H₁₄N₄O₃ · CH₃CO₂H
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBoucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
      Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
      Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
      Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
      Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
      Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.