Millipore Sigma Vibrant Logo

444290 MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817

View Products on Sigmaaldrich.com
444290
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
223472-31-9C₂₂H₂₈N₂O₆

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
444290-2MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 2 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
      Catalogue Number444290
      Brand Family Calbiochem®
      Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
      References
      ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
      Product Information
      CAS number223472-31-9
      FormOff-white solid
      Hill FormulaC₂₂H₂₈N₂O₆
      Chemical formulaC₂₂H₂₈N₂O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      444290-2MG 04055977186079

      Documentation

      MMP Inhibitor V - CAS 223472-31-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MMP Inhibitor V - CAS 223472-31-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      444290

      Références bibliographiques

      Aperçu de la référence bibliographique
      Okamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2009 RFH
      Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
      DescriptionAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number223472-31-9
      Chemical formulaC₂₂H₂₈N₂O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
      Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
      Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
      Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
      Yamada, A., et al. 2000. Inflamm. Res. 49, 144.