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454870 MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem

The MARK/Par-1 Activity Inhibitor, 39621 controls the biological activity of MARK/Par-1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Microtubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor, N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide

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454870
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Tableau de caractéristiques principal

CAS #Empirical Formula
895112-95-5C₂₁H₂₁N₃O₃S

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454870-10MG
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      Description
      OverviewA cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK-selective inhibitor (IC50 = 3.6 µM; [ATP] = 100 µM). Shown to effectively block primary rat cortical neuron axon growth (5.7 µm/hr vs 32.5 µm/hr with or without 20 µM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity in CHO cells (10 µM).
      Catalogue Number454870
      Brand Family Calbiochem®
      SynonymsMicrotubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor, N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide
      References
      ReferencesTimm, T., et al. 2011. J. Biol. Chem. 286, 41711.
      Product Information
      CAS number895112-95-5
      FormBeige solid
      Hill FormulaC₂₁H₂₁N₃O₃S
      Chemical formulaC₂₁H₂₁N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      454870-10MG 04055977204261

      Documentation

      MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MARK/Par-1 Activity Inhibitor, 39621 - CAS 895112-95-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      454870

      Références bibliographiques

      Aperçu de la référence bibliographique
      Timm, T., et al. 2011. J. Biol. Chem. 286, 41711.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-September-2012 JSW
      SynonymsMicrotubule Affinity Regulating Kinase Inhibitor, MAP Affinity Regulating Kinase Inhibitor, PAR1 Inhibitor, N-(2,5-Dimethylphenyl)-2-(4-(4-methoxyphenyl)-3-oxo-3,4-dihydropyrazin-2-ylthio)acetamide
      DescriptionA cell-permeable dihydropyrazinyl-thioacetamide that acts as an ATP-competitive MARK inhibitor (IC50 = 3.6 µM; [ATP] = 100 µM) with much reduced or little activity against GSK-3β, SAD-kinase B/BRSK-1, MARKK/TAO-1, Cdc2/cycB, and p38/SAPK (30%, 20%, 11%, 4%, and 0% inhibition, respectively; [inhibitor] = 50 µM). Shown to effectively block primary rat cortical neuron axon growth (5.7 µm/hr vs 32.5 µm/hr with or without 20 µM inhibitor) and prevent MARK2 overexpression-induced Tau Ser262 phosphorylation and cytotoxicity due to microtubule network breakdown in CHO cells (10 µM).
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number895112-95-5
      Chemical formulaC₂₁H₂₁N₃O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTimm, T., et al. 2011. J. Biol. Chem. 286, 41711.