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438210 LSF Inhibitor, FQI1 - Calbiochem

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Tableau de caractéristiques principal

Empirical Formula
C₁₈H₁₇NO₄

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
438210-10MG
Disponibilité limitée
Disponibilité limitée
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Interrompu(e)
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      Description
      OverviewA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
      Catalogue Number438210
      Brand Family Calbiochem®
      Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
      Application Data
      References
      ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
      Product Information
      FormWhite powder
      Hill FormulaC₁₈H₁₇NO₄
      Chemical formulaC₁₈H₁₇NO₄
      Quality LevelMQ100
      Biological Information
      Purity>92% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      438210-10MG 04055977187052