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508228 L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: gamma-glutamylcysteine synthetase
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508228
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Tableau de caractéristiques principal

CAS #Empirical Formula
83730-53-4C₈H₁₈N₂O₃S

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      Description
      OverviewA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
      Catalogue Number508228
      Brand Family Calbiochem®
      References
      ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
      Product Information
      CAS number83730-53-4
      FormWhite powder
      Hill FormulaC₈H₁₈N₂O₃S
      Chemical formulaC₈H₁₈N₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetgamma-glutamylcysteine synthetase
      Purity≥97% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5082280001 04055977261790

      Documentation

      L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      DescriptionA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number83730-53-4
      Chemical formulaC₈H₁₈N₂O₃S
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.