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530537 JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem

A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC₅₀ = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: KDM4 Inhibitor

Primary Target: KDM4
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530537
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Tableau de caractéristiques principal

CAS #Empirical Formula
1586038-75-6C₁₈H₂₃NO₃

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      Description
      OverviewA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530537
      Brand Family Calbiochem®
      SynonymsKDM4 Inhibitor
      References
      ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.
      Product Information
      CAS number1586038-75-6
      FormGrey-green solid
      Hill FormulaC₁₈H₂₃NO₃
      Chemical formulaC₁₈H₂₃NO₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetKDM4
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5305370001 04055977260885

      Documentation

      JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Schiller, R., et al. 2014. ChemMedChem. 9,566.

      Informations techniques

      Titre
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2014 JSW
      SynonymsKDM4 Inhibitor
      DescriptionA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.
      FormGrey-green solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1586038-75-6
      Chemical formulaC₁₈H₂₃NO₃
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.