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420143 JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem

The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide

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420143
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1164153-22-3C₂₇H₂₇N₅O₅

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      Description
      OverviewA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
      Catalogue Number420143
      Brand Family Calbiochem®
      Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
      References
      ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
      Product Information
      CAS number1164153-22-3
      FormOff-white solid
      Hill FormulaC₂₇H₂₇N₅O₅
      Chemical formulaC₂₇H₂₇N₅O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420143-5MG 04055977211092

      Documentation

      JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420143

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
      DescriptionA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1164153-22-3
      Chemical formulaC₂₇H₂₇N₅O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.