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688002 InSolution™ Y-27632 in DMSO - Calbiochem

InSolution™ Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK).

InSolution™ Y-27632 in DMSO - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI

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688002
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Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₁₄H₂₁N₃O•2HCl•H₂O

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      Description
      OverviewA highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
      Catalogue Number688002
      Brand Family Calbiochem®
      Synonyms(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
      References
      ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science 285, 895.
      Uehata, M., et al. 1997. Nature 389, 990.
      Product Information
      FormLiquid
      FormulationA 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
      Hill FormulaC₁₄H₂₁N₃O•2HCl•H₂O
      Chemical formulaC₁₄H₂₁N₃O•2HCl•H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Global Trade Item Number
      Référence GTIN
      688002-1MG 04055977225464