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566321 InSolution™ Sirtinol - Calbiochem

InSolution™ Sirtinol - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III

Primary Target: ySir2
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566321
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₆H₂₂N₂O₂

Prix & Disponibilité

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566321-1MG
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      Description
      Catalogue Number566321
      Brand Family Calbiochem®
      Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
      References
      ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
      Hill FormulaC₂₆H₂₂N₂O₂
      Chemical formulaC₂₆H₂₂N₂O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetySir2
      Primary Target IC<sub>50</sub>48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      566321-1MG 04055977191387

      Documentation

      InSolution™ Sirtinol - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Sirtinol - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      566321

      Références bibliographiques

      Aperçu de la référence bibliographique
      Mai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.

      Fiche technique

      Titre
      SIRTainty™ Class III HDAC Assay
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-October-2007 JSW
      Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
      DescriptionA cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
      FormLiquid
      FormulationA 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₂₂N₂O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.