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420128 InSolution™ JNK Inhibitor II - Calbiochem

The InSolution™ JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ JNK Inhibitor II - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: JNK 1, JNK 2, JNK 3
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420128
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₄H₈N₂O

Prix & Disponibilité

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420128-5MG
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      		 Ampoule plast. 5 mg
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      Description
      Catalogue Number420128
      Brand Family Calbiochem®
      References
      ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
      Product Information
      ATP CompetitiveY
      FormYellowish brown liquid
      FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
      Hill FormulaC₁₄H₈N₂O
      Chemical formulaC₁₄H₈N₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK 1, JNK 2, JNK 3
      Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420128-5MG 04055977188066

      Documentation

      InSolution™ JNK Inhibitor II - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ JNK Inhibitor II - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420128

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2008 RFH
      DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
      FormYellowish brown liquid
      FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₈N₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
      Toxicity Irritant
      ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.