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345733 Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

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Tableau de caractéristiques principal

Empirical Formula
C₆₄H₁₁₈N₂O₂₁ · NH₄

Prix & Disponibilité

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345733-500UG
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      Ampoule plast. 500 μg
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      Description
      OverviewContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
      M.W. 1198.5 (based on stearoyl - 18:0).
      Catalogue Number345733
      Brand Family Calbiochem®
      SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
      References
      ReferencesKatoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetProtein kinase C, EGF-receptor tyrosine kinase
      Primary Target IC<sub>50</sub>100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Référence GTIN
      345733-500UG 04055977193824