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345733 Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

Contains mainly N-acetylneuraminic acid.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄

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345733
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₆₄H₁₁₈N₂O₂₁ · NH₄

Prix & Disponibilité

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345733-500UG
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      		 Ampoule plast. 500 μg
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      Description
      OverviewContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
      M.W. 1198.5 (based on stearoyl - 18:0).
      Catalogue Number345733
      Brand Family Calbiochem®
      SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
      References
      ReferencesKatoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase C, EGF-receptor tyrosine kinase
      Primary Target IC<sub>50</sub>100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      345733-500UG 04055977193824

      Documentation

      Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      345733

      Références bibliographiques

      Aperçu de la référence bibliographique
      Katoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

      Brochure

      Titre
      Gangliosides Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 RFH
      SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
      DescriptionContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC50 = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
      FormWhite solid
      Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityChloroform:Methanol (2:1)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesKatoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.