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505277 GTS-21 Dihydrochloride (DMBX-A) - CAS 156223-05-1 - Calbiochem

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Synonymes: E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21

Primary Target: α7 nAChR
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505277
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Tableau de caractéristiques principal

CAS #Empirical Formula
156223-05-1C₁₉H₂₀N₂O₂•2HCl

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      Description
      OverviewA partial agonist selective for α7 nAChRs (EC50 = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer's disease studies.
      Catalogue Number505277
      Brand Family Calbiochem®
      SynonymsE)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21
      References
      ReferencesKox, M., et al. 2011. Br. J. Anaesth. 107, 559.
      Kox, M., et al., 2011. Shock. 36, 5.
      Rosas-Ballina, M., et al. 2009. Mol. Med. 15, 195.
      Briggs, A., et al. 1997. Pharmacol. Biochem. Behav. 57, 231.
      Product Information
      CAS number156223-05-1
      FormYellow solid
      Hill FormulaC₁₉H₂₀N₂O₂•2HCl
      Chemical formulaC₁₉H₂₀N₂O₂•2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα7 nAChR
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5052770001 04055977243635

      Documentation

      GTS-21 Dihydrochloride (DMBX-A) - CAS 156223-05-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kox, M., et al. 2011. Br. J. Anaesth. 107, 559.
      Kox, M., et al., 2011. Shock. 36, 5.
      Rosas-Ballina, M., et al. 2009. Mol. Med. 15, 195.
      Briggs, A., et al. 1997. Pharmacol. Biochem. Behav. 57, 231.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      SynonymsE)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21
      DescriptionA partial agonist selective for α7 nAChRs (EC50 = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer's disease studies.
      FormYellow solid
      CAS number156223-05-1
      Chemical formulaC₁₉H₂₀N₂O₂•2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or H₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKox, M., et al. 2011. Br. J. Anaesth. 107, 559.
      Kox, M., et al., 2011. Shock. 36, 5.
      Rosas-Ballina, M., et al. 2009. Mol. Med. 15, 195.
      Briggs, A., et al. 1997. Pharmacol. Biochem. Behav. 57, 231.