361550 Sigma-AldrichGSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem
BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Maintains self-renewal in human & mouse embryonic stem cel
More>> BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
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Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 667463-62-9 | C₁₆H₁₀BrN₃O₂ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 361550-10MG |
|
Ampoule plast. | 10 mg |
|
— | |
| 361550-1MG |
|
Ampoule plast. | 1 mg |
|
— | |
| 361550-30MG |
|
Ampoule plast. | 30 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available. |
| Catalogue Number | 361550 |
| Brand Family | Calbiochem® |
| Synonyms | BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime |
| Product Information | |
|---|---|
| CAS number | 667463-62-9 |
| ATP Competitive | Y |
| Form | Purple solid |
| Hill Formula | C₁₆H₁₀BrN₃O₂ |
| Chemical formula | C₁₆H₁₀BrN₃O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | GSK-3α/β |
| Primary Target IC<sub>50</sub> | 5 nM against GSK-3α/β |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information | |
|---|---|
| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 361550-10MG | 04055977214079 |
| 361550-1MG | 04055977214062 |
| 361550-30MG | 04055977214086 |