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341205 Etoposide - CAS 33419-42-0 - Calbiochem

Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.

Etoposide - CAS 33419-42-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: VP-16

Primary Target: topoisomerase 2
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      33419-42-0C₂₉H₃₂O₁₃
      Description
      OverviewA cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
      Catalogue Number341205
      Brand Family Calbiochem®
      SynonymsVP-16
      References
      ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
      Product Information
      CAS number33419-42-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₃₂O₁₃
      Chemical formulaC₂₉H₃₂O₁₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationEtoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2 µM). Displays anti-tumor activity.
      Biological Information
      Primary Targettopoisomerase 2
      Primary Target IC<sub>50</sub>59.2 µM inhibiting topoisomerase II
      Purity>95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKC0190000
      Safety Information
      R PhraseR: 22-45

      Harmful if swallowed.
      May cause cancer.
      S PhraseS: 26-36/37/39-45-53

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      341205 0

      Documentation

      Etoposide - CAS 33419-42-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Etoposide - CAS 33419-42-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      341205

      Références bibliographiques

      Aperçu de la référence bibliographique
      De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2023 JSW
      SynonymsVP-16
      DescriptionA cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.
      FormWhite solid
      CAS number33419-42-0
      RTECSKC0190000
      Chemical formulaC₂₉H₃₂O₁₃
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 3886
      ReferencesDe Lange, A.M., et al. 1995. J. Virol. 69, 2082.
      Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
      Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
      Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
      Wazniak, A.J., et al. 1991. J. Clin. Oncol. 9, 70.
      Einhorn, L.H., et al. 1988. J. Clin. Oncol. 6, 451.
      Issel, B.F. 1982. Cancer Chemother. Pharmacol. 7, 73.