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328005 ERK Activation Inhibitor Peptide II, Cell-Permeable - Calbiochem

The ERK Activation Inhibitor Peptide II, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MTPTAT-G-MEK1₁₃, H-GYGRKKRRQRRR-G-MPKKKPTPIQLNP-NH₂, Erk Inhibitor V

Primary Target: MEK
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328005
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₃₆H₂₄₁N₅₃O₃₁S

Prix & Disponibilité

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328005-1MG
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      Description
      OverviewA cell-permeable and reversible 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that is fused to the HIV-TAT membrane translocating peptide (MTP) sequence via a glycine linker. Acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 210 nM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 29 µM). Does not affect the activation of JNKs or p38.
      Catalogue Number328005
      Brand Family Calbiochem®
      SynonymsMTPTAT-G-MEK1₁₃, H-GYGRKKRRQRRR-G-MPKKKPTPIQLNP-NH₂, Erk Inhibitor V
      References
      ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₆H₂₄₁N₅₃O₃₁S
      Chemical formulaC₁₃₆H₂₄₁N₅₃O₃₁S
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMEK
      Primary Target IC<sub>50</sub>210 nM against MEK; 29 µM in blocking ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      328005-1MG 04055977196344

      Documentation

      ERK Activation Inhibitor Peptide II, Cell-Permeable - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      ERK Activation Inhibitor Peptide II, Cell-Permeable - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      328005

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      SynonymsMTPTAT-G-MEK1₁₃, H-GYGRKKRRQRRR-G-MPKKKPTPIQLNP-NH₂, Erk Inhibitor V
      DescriptionA cell-permeable and reversible 13-amino acid peptide corresponding to the N-terminus of MAPK/ERK kinase (MEK or MAPKK) that is fused to the HIV-TAT membrane translocation peptide (MTP) sequence via a glycine linker. Acts as a specific inhibitor of ERK activation by MEK1 and the downstream transcriptional activity of ELK1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 210 nM in vitro). Potently blocks ERK in PMA-stimulated NIH3T3 cells and NGF-treated PC12 cells (IC50 = 29 µM). Does not inhibit the activation of c-jun N-terminal kinases (JNKs) or p38 MAP kinase.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₆H₂₄₁N₅₃O₃₁S
      Peptide SequenceH-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.