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265005 Dexamethasone - CAS 50-02-2 - Calbiochem

Dexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).

Dexamethasone - CAS 50-02-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 9α-Fluoro-16α-methylprednisolone

Primary Target: Phosphorylation of rb protein
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265005
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Tableau de caractéristiques principal

CAS #Empirical Formula
50-02-2C₂₂H₂₉FO₅

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265005-100MG
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      		 Ampoule plast. 100 mg
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      Description
      OverviewMost active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G1/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+ - K+ pump. Induces apoptosis in human thymocytes.
      Catalogue Number265005
      Brand Family Calbiochem®
      Synonyms9α-Fluoro-16α-methylprednisolone
      References
      ReferencesReil, T.D., et al. 2000. J. Surg. Res. 92, 108.
      Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
      Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
      Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
      Donis, J.A., et al. 1993. Biotechniques 15, 786.
      Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
      Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
      Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
      Warters, R.L. 1992. Cancer Res. 52, 883.
      Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
      Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
      Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.
      Product Information
      CAS number50-02-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₉FO₅
      Chemical formulaC₂₂H₂₉FO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).
      Biological Information
      Primary TargetPhosphorylation of rb protein
      Primary Target IC<sub>50</sub>5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSTU3980000
      Safety Information
      R PhraseR: 36/37/38-43-63

      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 24-26-36/37

      Avoid contact with skin.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and gloves.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Global Trade Item Number
      Référence GTIN
      265005-100MG 04055977198508