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251400 D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Tricyclodecan-9-yl-xanthogenate, K

Primary Target: pc-specificphopholipase c
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251400
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Tableau de caractéristiques principal

CAS #Empirical Formula
83373-60-8C₁₁H₁₅OS₂ · K

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251400-5MG
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      Description
      OverviewSelective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
      Catalogue Number251400
      Brand Family Calbiochem®
      SynonymsTricyclodecan-9-yl-xanthogenate, K
      References
      ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
      Lozanski, G., et al. 1997. Biochem. J. 328, 271.
      Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
      Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
      Schutze, S., et al. 1992. Cell 71, 765.
      Sauer, G., et al. 1990. Cancer Lett. 53, 97.
      Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
      Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
      Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
      Product Information
      CAS number83373-60-8
      ATP CompetitiveN
      FormOff-white powder
      Hill FormulaC₁₁H₁₅OS₂ · K
      Chemical formulaC₁₁H₁₅OS₂ · K
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetpc-specificphopholipase c
      Primary Target K<sub>i</sub>5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      251400-5MG 04055977199208

      Documentation

      D609, Potassium Salt - CAS 83373-60-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      D609, Potassium Salt - CAS 83373-60-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      251400

      Références bibliographiques

      Aperçu de la référence bibliographique
      Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
      Lozanski, G., et al. 1997. Biochem. J. 328, 271.
      Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
      Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
      Schutze, S., et al. 1992. Cell 71, 765.
      Sauer, G., et al. 1990. Cancer Lett. 53, 97.
      Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
      Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
      Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2010 JSW
      SynonymsTricyclodecan-9-yl-xanthogenate, K
      DescriptionSelective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).
      FormOff-white powder
      CAS number83373-60-8
      Chemical formulaC₁₁H₁₅OS₂ · K
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (25 mg/ml) and DMSO (25 mg/ml). Note: tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
      Toxicity Standard Handling
      ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
      Lozanski, G., et al. 1997. Biochem. J. 328, 271.
      Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
      Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
      Schutze, S., et al. 1992. Cell 71, 765.
      Sauer, G., et al. 1990. Cancer Lett. 53, 97.
      Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
      Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
      Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.