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110145 D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
3102-57-6C₂₀H₃₉NO₃

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110145-5MG
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      Description
      OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
      Catalogue Number110145
      Brand Family Calbiochem®
      SynonymsC₂ Ceramide
      References
      ReferencesWestwick, J.K., et al. 1995. J. Biol. Chem. 270, 22689.
      Cifone, M.G., et al. 1994. J. Exp. Med. 180, 1547.
      Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
      Bielawska, A., et al. 1993. J. Biol. Chem. 268, 26226.
      Obeid, L.M., et al. 1993. Science 259, 1769.
      Ballou, L.R., et al. 1992. J. Biol. Chem. 267, 20044.
      Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
      Product Information
      CAS number3102-57-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₃₉NO₃
      Chemical formulaC₂₀H₃₉NO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetInhibits cell growth and induces apoptosis in HL-60 cells
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.
      Global Trade Item Number
      Référence GTIN
      110145-5MG 07790788055585