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567726 D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Cerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide

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567726
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Tableau de caractéristiques principal

CAS #Empirical Formula
123-78-4C₁₈H₃₇NO₂

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567726-10MG
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      Description
      OverviewHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.
      Catalogue Number567726
      Brand Family Calbiochem®
      SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
      References
      Product Information
      CAS number123-78-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₃₇NO₂
      Chemical formulaC₁₈H₃₇NO₂
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>2.8 µM against PKC
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      567726-10MG 04055977190830

      Documentation

      D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      567726

      Brochure

      Titre
      Bioactive Lipids Technical Bulletin
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
      DescriptionHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
      FormWhite solid
      CAS number123-78-4
      Chemical formulaC₁₈H₃₇NO₂
      Purity≥98% by TLC
      SolubilityMethanol (1 mg/ml), Chloroform (1 mg/ml), or DMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
      Toxicity Irritant
      Merck USA index14, 8747