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219401 Cathepsin D, Human Liver

Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis.

Cathepsin D, Human Liver : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
219401
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Référence DisponibilitéConditionnement Qté Prix Quantité
219401-15U
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      		 Ampoule plast. 15 u
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      Maximum Quantity is
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      219401-30U
      Récupération des données relatives à la disponibilité...
      —
      Disponibilité limitée Disponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          		 Ampoule plast. 30 u
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          Maximum Quantity is
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          —
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          Description
          OverviewNative cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
          Catalogue Number219401
          Brand Family Calbiochem®
          References
          ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.
          Product Information
          CAS number9025-26-7
          Unit of DefinitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
          EC number3.4.23.5
          FormLyophilized
          FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥300 units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Référence GTIN
          219401-15U 04055977201710
          219401-30U 04055977201727

          Documentation

          Cathepsin D, Human Liver Certificats d'analyse

          TitreNuméro de lot
          219401

          Références bibliographiques

          Aperçu de la référence bibliographique
          Berchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.

          Brochure

          Titre
          Cathepsins and Related Products Technical Bulletin
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionNative cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
          FormLyophilized
          FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9025-26-7
          EC number3.4.23.5
          Purity≥90% by SDS-PAGE
          Specific activity≥300 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
          SolubilitySterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
          Toxicity Standard Handling
          Merck USA index14, 1905
          ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
          Barbi, G.P., et al. 1994. Oncology 51, 329.
          Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
          Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
          Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
          Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
          Erickson, A. 1989. J. Cell. Biochem. 40, 31.