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400012 Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

Caspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK

Primary Target: caspase-1
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400012
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
178603-78-6C₂₄H₃₃ClN₄O₈

Prix & Disponibilité

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400012-5MG
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      Description
      OverviewA cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
      Catalogue Number400012
      Brand Family Calbiochem®
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
      References
      ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Enari, M., et al. 1995. Nature 375, 78.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Thornberry, N., et al. 1992. Nature 356, 768.
      Product Information
      CAS number178603-78-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₄H₃₃ClN₄O₈
      Chemical formulaC₂₄H₃₃ClN₄O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCaspase-1 Inhibitor II, CAS 178603-78-6, is a cell-permeable, irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.
      Biological Information
      Primary Targetcaspase-1
      Primary Target K<sub>i</sub>760 pM against caspase-1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      400012-5MG 07790788049928

      Documentation

      Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      400012

      Références bibliographiques

      Aperçu de la référence bibliographique
      Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Enari, M., et al. 1995. Nature 375, 78.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Thornberry, N., et al. 1992. Nature 356, 768.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2010 JSW
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK
      DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
      FormWhite solid
      CAS number178603-78-6
      Chemical formulaC₂₄H₃₃ClN₄O₈
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CMK
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBrenner, B., et al. 1998. Cell Death Differ. 5, 29.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Enari, M., et al. 1995. Nature 375, 78.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Thornberry, N., et al. 1992. Nature 356, 768.
      Citation
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
      		•

      Produits & Applications associés

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors