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504041 CaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem

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Synonymes: (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV

Primary Target: TMEM16A-CaCC
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504041
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Tableau de caractéristiques principal

CAS #Empirical Formula
3562-84-3C₁₇H₁₂Br₂O₃

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      Description
      OverviewA cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500 nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150 µM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation.
      Catalogue Number504041
      Brand Family Calbiochem®
      Synonyms(3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV
      References
      ReferencesKobayashi, K., et al. 2012. Drug Metab. Pharmacokinet. In press.
      Zhang, C.H., et al. 2013. Am. J. Respir. Crit. Care Med. 187, 374.
      Huang, F., et al. 2012. Proc. Natl. Acad. Sci. USA. 109, 16354.
      Fujimori, S., et al. 2011. Nucleosides Nucleotides Nucleic Acids 30, 1035.
      Perez-Ruiz, F., et al. 1998. Ann. Rheum. Dis. 57, 545.
      Product Information
      CAS number3562-84-3
      FormWhite powder
      Hill FormulaC₁₇H₁₂Br₂O₃
      Chemical formulaC₁₇H₁₂Br₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetTMEM16A-CaCC
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 45

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      5040410001 04055977264234