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504914 CNQX - CAS 115066-14-3 - Calbiochem

CNQX - CAS 115066-14-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline

Primary Target: AMPA
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504914
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Tableau de caractéristiques principal

CAS #Empirical Formula
115066-14-3C₉H₄N₄O₄

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      Description
      OverviewA potent and competitive antagonist for AMPA/kainate receptors (Ki = 0.6 - 2.11 µM for GluA1-4 and Ki = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number504914
      Brand Family Calbiochem®
      Synonyms6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
      References
      ReferencesLee, S., et al. 2010. J. Neurophysiol. 103, 1728.
      King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
      Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.
      Product Information
      CAS number115066-14-3
      FormOff-white to yellow solid
      Hill FormulaC₉H₄N₄O₄
      Chemical formulaC₉H₄N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAMPA
      Primary Target K<sub>i</sub>0.6 – 2.11 →M for GluA1 – 4 and Ki
      Secondary targetKainate
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5049140001 04055977263688

      Documentation

      CNQX - CAS 115066-14-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      CNQX - CAS 115066-14-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      504914

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lee, S., et al. 2010. J. Neurophysiol. 103, 1728.
      King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
      Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2024 JSW
      Synonyms6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
      DescriptionA potent and competitive antagonist for AMPA/kainate receptors (Ki = 0.6 - 2.11 µM for GluA1-4 and Ki = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.
      FormOff-white to yellow solid
      CAS number115066-14-3
      Chemical formulaC₉H₄N₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, S., et al. 2010. J. Neurophysiol. 103, 1728.
      King, A., et al. 1992. Br. J. Pharmacol. 107, 375.
      Long, S. et al. 1990. Br. J. Pharmacol. 100, 850.Harris, K., et al. 1989. Brain Res. 5, 185Honore, T., et al. 1988. Science. 241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol. 156, 177.