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SCT067 BioTracker IRI-1 b-Amyloid Plaque Live Cell Dye

Live cell imaging probe for beta-amyloid plaques to study neurodegenrative diseases such as Alzheimer's disease.

SCT067
1 mg  
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      Fluorescence at Near-Infrared range
      Description
      Catalogue NumberSCT067
      DescriptionBioTracker IRI-1 b-Amyloid Plaque Live Cell Dye
      OverviewAlzheimer’s disease (AD) is a common progressive
      neurodegenerative disease eventually leading to fatality.
      Significant accumulation of pathological proteinaceous deposits
      in the brain, including Aβ plaques, are present decades before
      symptoms can be perceived. As such, the delay between
      pathological brain chemistry changes and symptoms creates a
      window of opportunity for potential treatments.

      BioTracker IRI-1 b-Amyloid plaque live cell dye is a near-infrared-emissive two-photon microscopy (TPM) dye with high affinity for Aß-fibrils. The dye demonstrates a ~167-fold increase in fluorescence in the presence of Aß-fibrils. SCT067 achieves this while maintaining large two-photon cross-section, a large signal to background ratio, high BBB permeability, and emission reaching into the near-infrared (NIR, > 650 nm). This dye has been used for ex-vivo and in vivo TPM imaging of Aß-fibrils in mouse brains.

      Spectral Properties
      For Two-photon microscopy.
      Excitation: 850 nm
      Emission: 580- 779 nm

      References
      Shin J et al. Harnessing Intramolecular Rotation to Enhance Two-Photon Imaging of Aß Plaques Through Minimizing Background fluorescence. Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5648-5652.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging probe for beta-amyloid plaques to study neurodegenrative diseases such as Alzheimer's disease.
      Key Applications
      • Cell Based Assays
      • Fluorescence
      • Neuroscience
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight249.74 g/ml
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceStructure confirmed by HNMR. Elemental analysis consistent with structure.
      Molar Mass: 249.74 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker IRI-1 b-Amyloid Plaque Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCT067 04061841072775