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SCT057 BioTracker ERthermAC Temperature-Sensitive Live Cell Dye

Live cell imaging thermosensitive dye to visualize heat production in brown adipocytes.

SCT057
1 mg  
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      Replacement Information
      Description
      Catalogue NumberSCT057
      DescriptionBioTracker ERthermAC Temperature-Sensitive Live Cell Dye
      OverviewBrown adipocyte tissue (BAT) has been shown to be present in human newborns, small infants, as well as adults. Stimulation of BAT energy expenditure is considered a potential new drug target for obesity and diabetes treatments, and there is increasing interest in the discovery of novel mechanisms and substances for this purpose. However, to facilitate the development of breakthrough therapies, it is essential that techniques to measure the signature function of BAT are readily available.

      The BioTracker ERthermAC thermosensitive live cell dye is a novel BODIPY-based dye that is capable of imaging heat production in individual brown adipocytes. The dye’s features such as small size, excellent cellular uptake, low cytotoxicity and robust photostability make it very biocompatible. Data obtained using this dye is comparable with that obtained by conventional methods measuring mitochondrial depolarization, oxygen consumption, and extracellular acidification rates, and with thermal power measurements obtained using the calScreener.

      Spectral Properties
      Absorption: 565 nm
      Emissions: 590 nm (Orange/Red) in polarized mitochondria
      Emissions: 527 nm (Green) in depolarized mitochondria

      References
      Kriszt R et al. Optical visualization of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 May 3;7(1):1383.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      HS Code3204 90 00
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging thermosensitive dye to visualize heat production in brown adipocytes.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight541.28 g/mol
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 541.28 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker ERthermAC Temperature-sensitive Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCT057 04054839008382