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MABS1300 Anti-asparagine synthetase Antibody, clone Z5808

This mouse monoclonal Anti-asparagine synthetase, clone Z5808, Cat. No. MABS1300 has been tested for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting for the detection of human Asparagine Synthetase.

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Research Category: Signaling Gene Symbol: ASNS, TS11 UniProt Number: P08243
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MABS1300
100 μg  
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      Replacement Information

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WB, ICC, IH(P), ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1300
      DescriptionAnti-asparagine synthetase Antibody, clone Z5808
      Alternate Names
      • Asparagine synthetase [glutamine-hydrolyzing]
      • Cell cycle control protein TS11
      • Glutamine-dependent asparagine synthetase
      Background InformationAsparagine synthetase [glutamine-hydrolyzing] (UniProt: P08243; also known as EC:6.3.5.4, Cell cycle control protein TS11, Glutamine-dependent asparagine synthetase) is encoded by the ASNS (also known as TS11) gene (Gene ID: 440) in human. Asparagine synthetase catalyzes the biosynthesis of L-asparagine from L-aspartate in an ATP-dependent manner. It contains one asparagine synthetase domain and one glutamine amidotransferase type-2 domain. ASNS transcription is enhanced by amino acid deprivation via a signal transduction pathway that senses amino acid availability. Mutations in ASNS gene are reported to result in asparagine synthetase deficiency that is characterized by microcephaly, severely delayed psychomotor development, progressive encephalopathy, and hyperekplexic activity. There has been much interest in the development of asparagine synthetase inhibitors for treatment of asparaginase-resistance leukemias and levels of asparagine synthetase have been considered as a potential biomarker in ovarian cancers.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in PBS with 0.01% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis mouse monoclonal Anti-asparagine synthetase, clone Z5808, Cat. No. MABS1300 has been tested for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting for the detection of human Asparagine Synthetase.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • ELISA
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected asparagine synthetase in human tonsil and human uterus tissues.

      Immunocytochemistry Analysis: A representative lot detected asparagine synthetase in Immunocytochemistry applications (Kusano-Arai, O., et. al. (2012). Hybridoma (Larchmt). 31(5):325-32).

      Flow Cytometry Analysis: A representative lot detected asparagine synthetase in Flow Cytometry applications (Kusano-Arai, O., et. al. (2012). Hybridoma (Larchmt). 31(5):325-32).

      ELISA Analysis: A representative lot detected asparagine synthetase in ELISA applications (Kusano-Arai, O., et. al. (2012). Hybridoma (Larchmt). 31(5):325-32).

      Western Blotting Analysis: A representative lot detected asparagine synthetase in Western Blotting applications (Kusano-Arai, O., et. al. (2012). Hybridoma (Larchmt). 31(5):325-32).
      Biological Information
      ImmunogenN-asparagine synthetase-budded virus.
      CloneZ5808
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone Z5808 detects Asparagine synthetase in human creast cancer, human tonsil, and human uterus. It targets an epitope within 50 amino acids from the N-terminal end.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ASNS
      • TS11
      Purification MethodAmmonium Sulfate
      UniProt Number
      Molecular Weight64.37 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human breast cancer tissues.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected asparagine synthetase in human breast cancer tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABS1300 04054839198939