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MABN1601 Anti-Vitamin D3 Receptor Antibody, clone 6F3.1

Anti-Vitamin D3 Receptor Antibody, clone 6F3.1, Cat. No. MABN1601, is a highly specific mouse monoclonal antibody that targets Vitamin D3 receptor and has been tested in Western Blotting.

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Research Category: Neuroscience Gene Symbol: VDR, NR1I1 UniProt Number: P11473
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MABN1601
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1601
      DescriptionAnti-Vitamin D3 Receptor Antibody, clone 6F3.1
      Alternate Names
      • Vitamin D3 receptor
      • 1
      • 25-dihydroxyvitamin D3 receptor
      • Nuclear receptor subfamily 1 group I member 1
      • VDR
      Background InformationVitamin D3 receptor (UniProt P11473; also known as 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR) is encoded by the VDR (also known as NR1I1) gene (Gene ID 7421) in human. VDR is a member of the superfamily of nuclear receptors for steroid hormones and acts as a ligand-inducible transcription factor that targets vitamin D responsive elements. Upon ligand binding, VDR complexes with the retinoid-X receptor (RXR), the heterodimer then targets hormone-response elements, resulting in transcription or transrepression of specific genes. Ligand binding also induces a conformational change at the C-terminal ligand-binding domain (LBD; a.a. 192-427), resulting in recruitment of the p160/SRC family coactivators whose acetylase activity plays an important role in transcription modulations via chromatin remodeling. VDR gene mutations are associated with type II vitamin D-resistant rickets and alopecia (hair loss).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Vitamin D3 Receptor Antibody, clone 6F3.1, Cat. No. MABN1601, is a highly specific mouse monoclonal antibody that targets Vitamin D3 receptor and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to the N-terninal of human vitamin D3 receptor.
      Clone6F3.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6F3.1 targets an epitope present at the N-terminal half of both spliced isoforms of human vitamin D3 receptor reported by UniProt (P11473).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VDR
      • NR1I1
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~50 kDa observed. 48.29/53.88 kDa (isoform 1/2) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in T47D cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected vitamin D3 receptor in 10 µg of T47D human breast cancer cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABN1601 04054839083662