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AB6019 Anti-Thymosin beta-4 Antibody

Anti-Thymosin beta-4 Antibody is an antibody against Thymosin beta-4 for use in WB & IC.

Anti-Thymosin beta-4 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: FX, TB4X, TMSB4, THYB4, PTMB4, TMSB4X, Fx UniProt Number: P62328
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AB6019
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB6019
      DescriptionAnti-Thymosin beta-4 Antibody
      Alternate Names
      • thymosin beta 4, X-linked
      • prothymosin beta-4
      • thymosin, beta 4
      • thymosin, beta 4, X chromosome
      • T beta-4
      Background InformationThymosin beta-4 is the most prevalent of the cytoplasmic G-actin binding proteins belonging to the highly conserved thymosin beta family. Known to bind actin monomers, Thymosin beta-4 sequesters G-actin in a manner that prevents actin polymerization. Thymosin beta-4 plays several important roles including induction of tissue remodeling, wound healing in both cell and tissue injuries, and cell differentiation via mechanisms that have yet to be fully elucidated. It is involved in the regulation of the cytoskeleton, and thereby influences an array of cellular processes. Within the brain, Thymosin beta-4 is associated with the neurite extension and migration of neurons. Expression has been observed in various hemopoietic and lymphoid malignant cell lines.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Recombinant Thymosin beta-4
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Thymosin beta-4 Antibody is an antibody against Thymosin beta-4 for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blot (Snap i.d.®) Analysis: 1 µg/mL from a previous lot detected Thymosin beta-4 on 10 µg of recombinant Thymosin beta-4.

      Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Thymosin beta-4 in NIH/3T3, HeLa, and A431 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the internal domain of human Thymosin beta-4.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityTh antibody recognizes the internal domain of Thymosin beta-4.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FX
      • TB4X
      • TMSB4
      • THYB4
      • PTMB4
      • TMSB4X
      • Fx
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Plays an important role in the organization of the cytoskeleton (by similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

      Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase (by similarity).

      SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton.

      TISSUE SPECIFICTY: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.

      INDUCTION: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda.

      SEQUENCE SIMILARITIES: Belongs to the thymosin beta family.
      Molecular Weight~ 33kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in recombinant Thymosin beta-4.

      Western Blot Analysis: 1 µg/mL of the antibody detected Thymosin beta-4 on 10 µg of recombinant Thymosin beta-4.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB6019 04053252551932

      Documentation

      Anti-Thymosin beta-4 Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Thymosin beta-4 Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-Thymosin beta-4 - 2120078 2120078
      Anti-Thymosin beta-4 - 2161201 2161201
      Anti-Thymosin beta-4 - 2420503 2420503
      Anti-Thymosin beta-4 - 2438698 2438698
      Anti-Thymosin beta-4 - 1956739 1956739
      Anti-Thymosin beta-4 - 2318056 2318056
      Anti-Thymosin beta-4 - 3387634 3387634
      Anti-Thymosin beta-4 - 3842844 3842844
      Anti-Thymosin beta-4 - 4040814 4040814
      Anti-Thymosin beta-4 - NG1905714 NG1905714
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