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05-1570 Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3

Use Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 (Rat Monoclonal Antibody) validated in WB, ELISA, IHC, FC to detect PRDM1 (BLIMP-1) also known as PR-domain zinc finger protein 1.

Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Epigenetics & Nuclear Function, Inflammation & Immunology Research Sub-Category: Transcription Factors, Transcription Factors Gene Symbol: BLIMP1, PRDM1, PRDI-BF1, BLIMP-1 UniProt Number: Q60636
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05-1570
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ELISA, IHC, FCRPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1570
      DescriptionAnti-PRDM1 (BLIMP-1) Antibody, clone 6D3
      Alternate Names
      • PR domain containing 1, with ZNF domain
      • PR-domain zinc finger protein 1
      • beta-interferon gene positive-regulatory domain I binding factor
      • Positive regulatory domain I-binding factor 1
      • PRDI-binding factor-1
      • Beta-interferon gene positive regulatory domain I-binding factor
      • B-lymphocyte-induced maturation protein 1
      • PR domain-containing protein 1
      • PRDI-binding factor 1
      • PR domain zinc finger protein 1
      Background InformationB-lymphocyte induced maturation protein (BLIMP-1) is a 100 kDa transcriptional repressor containing 1 DET domain and 4 C2H2-type zinc fingers. In the nucleus, BLIMP-1 is known to bind specifically with the Beta-interferon gene positive regulatory domain I (PRDI), and to interact with PRMT5. During B-cell differentiation, BLIMP-1 actively represses the transcription of the gene, c-myc, through binding its promoter and has been deemed a “master regulator” for terminal B-cell differentiation, as it is able to initiate the BCL1 cell developmental cascade.
      References
      Product Information
      FormatPurified
      Control
      • HL-60 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 (Rat Monoclonal Antibody) validated in WB, ELISA, IHC, FC to detect PRDM1 (BLIMP-1) also known as PR-domain zinc finger protein 1.
      Key Applications
      • Western Blotting
      • ELISA
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesELISA Analysis: A representative lot was used by an independent laboratory in ELISA. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)

      Flow Cytometry Analysis: A representative lot was used by an independent laboratory in FC. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse BLIMP-1.
      EpitopeRecognizes epitope located between amino acids 255-395 of BLIMP-1
      Clone6D3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityRecognizes BLIMP-1
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BLIMP1
      • PRDM1
      • PRDI-BF1
      • BLIMP-1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

      SUBUNIT STRUCTURE: Interacts with PRMT5. Ref.5

      SUBCELLULAR LOCATION: Nucleus (By similarity).

      SEQUENCE SIMILARITIES: Contains 4 C2H2-type zinc fingers.

      Contains 1 SET domain.

      SEQUENCE CAUTION: The sequence AAI29802.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
      Molecular Weight~ 95 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HL-60 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected BLIMP-1 on 10 µg of HL-60 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      05-1570 04053252641367

      Documentation

      Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 Certificats d'analyse

      TitreNuméro de lot
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 2436811 2436811
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 2036705 2036705
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 2318058 2318058
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 3385828 3385828
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 3601734 3601734
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 3720636 3720636
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 3827474 3827474
      Anti-PRDM1 (BLIMP-1), clone 6D3 - 4109604 4109604
      Anti-PRDM1 (BLIMP-1), clone 6D3 - NG1926423 NG1926423
      Anti-PRDM1 (BLIMP-1), clone 6D3 - NRG1771415 NRG1771415
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