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MABT179 Anti-Osterix (SP7) Antibody, clone 6B12.1

Detect the Osterix (SP7) protein using this Anti-Osterix (SP7), clone 6B12.1 validated for use in WB & IHC.

Anti-Osterix (SP7) Antibody, clone 6B12.1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Research Sub-Category: Cytoskeletal Signaling Gene Symbol: SP7, OSX UniProt Number: Q8TDD2
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MABT179
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT179
      DescriptionAnti-Osterix (SP7) Antibody, clone 6B12.1
      Alternate Names
      • Transcription factor Sp7
      • Zinc finger protein osterix
      Background InformationOSTERIX, or SP7, is a zinc finger-containing, osteoblast-specific transcription factor that is distinctly expressed in all developing bones, and is a key requirement for the differentiation of pre-osteoblasts into fully functional osteoblasts. While research on the actual functional mechanisms of OSTERIX is still on-going, current findings indicate that OSTERIX expression is induced by BMP-2 and Dlx5, and operates downstream of RUNX2, supporting its role in mesenchymal stem cell differentiation. Further studies also indicate that the OSTERIX transcription factor may also play a role in negatively regulating the Wnt/β-catenin signaling pathways and the proliferation of osteroblast cell types during embryonic osteogenesis.
      References
      Product Information
      FormatPurified
      Control
      • SW1353 cell lysate
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the Osterix (SP7) protein using this Anti-Osterix (SP7), clone 6B12.1 validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Isocitrate dehydrogenase in rat tooth tissue. Nuclear staining may be observed in epithelial cells in some tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Osterix.
      Clone6B12.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SP7
      • OSX
      UniProt Number
      Molecular Weight~45 kDa observed. An uncharacterized band may appear at ~160 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SW1353 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Osterix in 10 µg of SW1353 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABT179 04053252858192

      Documentation

      Anti-Osterix (SP7) Antibody, clone 6B12.1 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Osterix (SP7) Antibody, clone 6B12.1 Certificats d'analyse

      TitreNuméro de lot
      Anti-Osterix (SP7), clone 6B12.1 - Q2139348 Q2139348
      Anti-Osterix (SP7), clone 6B12.1 - 2299591 2299591
      Anti-Osterix (SP7), clone 6B12.1 - 3439188 3439188
      Anti-Osterix (SP7), clone 6B12.1 - 3835307 3835307
      Anti-Osterix (SP7), clone 6B12.1 -2816572 2816572
      Anti-Osterix (SP7), clone 6B12.1 Monoclonal Antibody 3049396